Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Rao, Surepalli Ram Mohan
- Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination:Optimization and Characterization
Abstract Views :173 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014., IN
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 3 (2017), Pagination: 114-122Abstract
The present study was undertaken to develop controlled porosity osmotic pump tablets of zidovudine-lamivudine combination. The tablets were prepared by wet granulation method using HPMC E5LV, and osmogen was prinicipal ingredients a dose of 300mg zidovudine-150 mg lamivudine twice daily. The coating solution of core tablets were prepared by using cellulose acetate, poly ethylene glycol of different grades, sorbitol and acetone to quantity sufficient for different batches. The prepared tablets were evaluated for pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among developed formulations CS4 batch show 96.31% drug release in 8 h for zidovudine and 97.83% for lamivudine in 8 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon-Crowell model. The result of optimized formulation was independent of the pH and agitation intensity. Short term stability study (at 40±2ºC / 75±5% RH for three months) on the best formulation indicated that there were no significant changes in thickness, friability, weight variation, drug content and in vitro drug release.Keywords
AIDS, Wet Granulation, In Vitro Drug Release, Stability Study.
References
- Barre Sinoussi F, Chermann JC, Rey F et al. “Isolation of a T lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome(AIDS)”, Science, 220:868-871,1983.
- UNAIDS, Review of data from People Living with HIV Stigma Index surveys conducted in more than 65 countries, 2016.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M. (2017) A Review on Prevention and Treatment of Aids. Pharm Pharmacol Int J 5(1): 00108.
- Michael J. Mugavero, Charles B. Hicks, HIV resistance and the effectiveness of combination antiretroviral treatment. Drug Discovery Today: Therapeutic strategies 2004; 1(4):529-535.
- Sahoo CK, Rao SRM, Sudhakar M and Sahoo NK. Advances in osmotic drug delivery system. J of Chemical and Pharmaceutical Research. 2015; 7:252-273.
- Verma RK, Krishna DM, Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J control release; 2000; 79:7-27.
- Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA. Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen International Journal for Pharmaceutical Research ScholarsV-1, I-2, 2012,254-267.
- Edavalath S, Shivanand K, Prakasam K, Rao BP, Divakar G. Formulation development and optimization of controlled Porosity osmotic pump tablets of diclofenac sodium.Int.J.Pharm.Pharm.Sci.2011;3(1):80-87.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M, Satyanarayana K.A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy, Cairo University 2015;53 (2):195-205.
- Anju CL, Palanichamy S, Rajesh M, Ramasubramaniyan P, Solairaj P. Formulation and evaluation of osmotic drug delivery system of ibuprofen. Ars Pharm.2014;55(4):44-51.
- Sahoo CK, Rao SRM, Sudhakar M. Evaluation of controlled porosity osmotic pump tablets: a review Research J. Pharm. and Tech. 2015; 8(12):119-125.
- Sahoo CK, Rao SRM, Sudhakar M and Kokkula S. The kinetic modeling of drug dissolution for drug delivery systems: an overview. Der Pharmacia Lettre 2015;7(9):186-194.
- Costa P, Lobo JMS. Modelling and comparison of dissolution profiles, European J of Pharmaceutical Sciences,2001;13:123-133.
- Banerjee A, Verma PRP, Gore S. Controlled porosity solubility modulated osmotic pump tablets of Gliclazide. AAPS Pharm Sci Tech 2015;16(3):554-568.
- Khan ZA, Tripathi R, Misha B. Design and evaluation of enteric coated microporous osmotic pump tablet(ECMOPT) of quetiapine fumarate for the treatment of psychosis. Acta Poloniae –Drug Research 2012;69(6):1125-1136.
- Kumaravelrajan R, Narayanan N, Suba V. Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination. Lipids in Health and Disease.2011;10:51.
- Kanagale P, Lohay BB, Misra A, Davadra P, Kini R. Formulation and Optimization of Porous Osmotic Pump based Controlled Release System of Oxybutynin. AAPS Pharm SciTech. 2007;8(3):E1-E7.
- Syed MS, Lahoti S, Syed AA. Controlled porosity osmotic tablet of atenolol: in vitro and in vivo evaluation, Marmara Pharmaceutical Journal,2016;20:325-332.